2 edition of The Role of apoptosis in development, tissue homeostasis, and malignancy found in the catalog.
The Role of apoptosis in development, tissue homeostasis, and malignancy
|Statement||edited by T.M. Dexter, M.C. Raff, and A.H. Wyllie|
|Contributions||Dexter, T. Michael, 1945-, Raff, Martin C, Wyllie, A. H., Royal Society (Great Britain)|
|The Physical Object|
|Pagination||ix, 101 p. :|
|Number of Pages||101|
|LC Control Number||96003598|
In Medical Cell Biology (Third Edition), SUMMARY. Apoptosis is a morphologically and biochemically distinct form of programmed cell death that plays an essential role during embryologic development, after birth, and during adulthood. However, deregulation of apoptosis is involved in the pathogenesis of a variety of human diseases. Since the late s, the core . Liling Yang et al. reported in the Feb. 15, , issue of Cancer Research the results of their work in the role played by a defective déath signal in a type of lung cancer cells called NCI-H (human non-small cell lung cancer cells). They found that the X-linked inhibitor of apoptosis protein (XIAP) is overexpressed in H cells.
scribble (scrib) is a cell-polarity determinant in Drosophila and human. Cell polarity plays a crucial role in the maintenance of tissue homeostasis and its disruption leads to neoplastic cancer progression. However, the underlying mechanisms by which loss of cell-polarity regulators drives cancer progression are poorly known. In this study, we have explored the tumor . Apoptosis plays a crucial role in tissue homeostasis, development and many diseases. The relevance of Apaf1, the molecular core of apoptosome, has been underlined in mitochondria-dependent apoptosis, which according to a growing body of evidence, is involved in various pathologies where the equilibrium of life-and-death is dysregulated.
Apoptosis; Inhibition of apoptosis; Programmed cell death, or apoptosis, is a genetically regulated process that plays an important role in development and homeostasis in metazoans ().Abnormalities in apoptosis have been linked to a variety of human diseases, including cancer, neurodegeneration, and autoimmune disorders (2, 3).There are two well-characterized . Senescent cells are thought to impair tissue function, and their genetic clearance can delay features of aging. Identifying how senescent cells avoid apoptosis allows for the prospective design of anti-senescence compounds to address whether homeostasis can also be restored. Here, we identify FOXO4 as a pivot in senescent cell viability.
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The past five years have witnessed a remarkable development of interest in cell death 'from inside and malignancy book. After 30 years of relative obscurity, its quantitative importance in the building and maintenance of normal tissues, the subtle strategies involved in its regulation, and its significance in the pathogenesis of diseases of major social importance are becoming clear.
The Role of Apoptosis in Development, Tissue Homeostasis and Malignancy: Death from inside out - Kindle edition by Dexter, R.M., Wyllie, A.H., Raff, M.C.
Download it once and read it on your Kindle device, PC, phones or tablets. Medicine & Health Sciences The Role of Apoptosis in Development, Tissue Homeostasis and Malignancy: Death from inside out th Edition by R.M. Dexter (Author), A.H. Wyllie (Author), M.C. Raff (Author) & 0 moreCited by: 3. The Role of Apoptosis in Development, Tissue Homeostasis and Malignancy Death from inside out Authors: Dexter, R.M., Wyllie, A.H., Raff, M.C.
The role of apoptosis in development, tissue homeostasis, and malignancy: death from inside out. Apoptosis plays a crucial role in tissue homeostasis, development and many diseases. The relevance of Apaf1, the molecular core of apoptosome, has been underlined in mitochondria-dependent.
Programmed cell death (PCD) or apoptosis is a mechanism which is crucial for all multicellular organisms to control cell proliferation and maintain tissue homeostasis as well as eliminate harmful or unnecessary cells from an organism.
Defects in the physiological mechanisms of apoptosis may contribute to different human diseases like cancer. Apoptosis is a highly regulated mechanism of cell The Role of apoptosis in development, essential in development and tissue homeostasis.
Apoptosis can occur via the extrinsic pathway, with ligand binding to death receptors on the cell surface, or via an internal pathway involving the mitochondria. Apoptosis, a major form of programmed cell death, is an important mechanism to remove extra or unwanted cells during development.
In tissue homeostasis apoptosis also acts as a monitoring machinery to eliminate damaged cells in response to environmental stresses.
Apoptosis, a genetically conserved pathway in all metazoans, is both essential for the generation of multicellular tissues during embryonic development as well as the maintenance of cellular. Keywords:Apoptosis, resveratrol, cancer. Abstract: Tissue homeostasis is maintained by tight control of signaling events that regulate cell death and cell survival.
Apoptosis or programmed cell death plays a key role in maintaining tissue homeostasis under various conditions during normal development and in the adult organism. Apoptosis, a major form of programmed cell death, is an important mechanism to remove extra or unwanted cells during development.
In tissue homeostasis apoptosis also acts as a monitoring machinery to eliminate damaged cells in response to environmental stresses. Regulated cell death has essential functions in development and in adult tissue homeostasis. Necroptosis is a newly discovered pathway of regulated necrosis.
Apoptosis also plays an essential role in the development and maintenance of a healthy immune system. When B and T cells (immune cells that bind specific molecules) are first produced, they’re tested to see if they react against any of the body’s own “self” components.
Cells that do are eliminated right away by apoptosis. A crucial role for apoptosis is seen during morphogenesis and tissue remodeling. The areas of interdigital cell death during limb development provide a paradigmatic model of massive cell.
Apoptosis plays a critical role during normal development and homeostasis of adult tissues. Consequently, deregulation of apoptosis is commonly associated with diseases ranging from cancer to neurodegeneration. Apoptosis and Development, the latest volume of Current Topics in Developmental Biology continues the legacy of this premier serial with quality chapters authored by leaders in the field.
This volume covers research methods in apoptosis and development, and includes sections on such topics as the non-lethal role of apoptotic proteins and germ. Programmed cell death (PCD) and cell survival are two sides of the same coin. Autophagy and apoptosis are crucial processes during embryo development of Invertebrates and Vertebrates organisms, as they are necessary for the formation of a new organism, starting from a fertilized egg.
Fertilization triggers cell remodeling from each gamete to a totipotent zygote. Get this from a library. Death from inside out: the role of apoptosis in development, tissue homeostasis and malignancy: proceedings of a Royal Society Discussion Meeting held on 23 and 24 February [T Michael Dexter; Martin C Raff; A H Wyllie; Royal Society (Great Britain).
Discussion Meeting]. Regulation of Apoptosis. Most animal cells have the ability to self-destruct by undergoing apoptosis, a morphologically distinct form of programmed cell death ().The proper regulation of apoptosis is critical for both development and tissue homeostasis, and inhibition of apoptosis contributes to the development and progression of cancer (2, 3).A central step for the execution of apoptosis.
MOMP is regulated by the Bcl-2 family of proteins. This pathway plays important roles not only in normal development, maintenance of tissue homeostasis and the regulation of immune system, but also in human diseases such as immune disorders, neurodegeneration and cancer.Apoptosis plays a fundamental role in many physiological processes such as tissue development, and the immune response.
Thus, regulation of apoptosis is important for tissue homeostasis and its deregulation can lead to a variety of pathological conditions including carcinogenesis and chemo-resistance.Apoptosis is a normal aspect of human physiology ensuring tissue homeostasis.
of the characteristics of cancer. Defects in the physiological mechanisms of apoptosis contribute to the pathological cell expansion and to the development and progression of cancer. Resistance of malignant cells to cancer therapeutic.